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Citació: Mestres, G.; Le Van, C.; Ginebra, M.P. Silicon-stabilized alpha-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response. "Acta biomaterialia", 31 Gener 2012, vol. 8, núm. 3, p. 1169-1179.
Títol: Silicon-stabilized alpha-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response
Autor: Mestres Beà, Gemma Veure Producció científica UPC; Le Van, Clemence; Ginebra Molins, Maria Pau Veure Producció científica UPC
Data: 31-gen-2012
Tipus de document: Article
Resum: α-Tricalcium phosphate (α-TCP) is widely used as a reactant in calcium phosphate cements. This work aims at doping α-TCP with silicon with a twofold objective. On the one hand, to study the effect of Si addition on the stability and reactivity of this polymorph. On the other, to develop Si-doped cements and to evaluate the effect of Si on their in vitro cell response. For this purpose a calcium-deficient hydroxyapatite was sintered at 1250 °C with different amounts of silicon oxide. The high temperature polymorph α-TCP was stabilized by the presence of silicon, which inhibited reversion of the β → α transformation, whereas in the Si-free sample α-TCP completely reverted to the β-polymorph. However, the β–α transformation temperature was not affected by the presence of Si. Si–α-TCP and its Si-free counterpart were used as reactants for a calcium phosphate cement. While Si–α-TCP showed faster hydrolysis to calcium-deficient hydroxyapatite, upon complete reaction the crystalline phases, morphology and mechanical properties of both cements were similar. An in vitro cell culture study, in which osteoblast-like cells were exposed to the ions released by both materials, showed a delay in cell proliferation in both cases and stimulation of cell differentiation, more marked for the Si-containing cement. These results can be attributed to strong modification of the ionic concentrations in the culture medium by both materials. Ca-depletion from the medium was observed for both cements, whereas continuous Si release was detected for the Si-containing cement.
ISSN: 1742-7061
URI: http://hdl.handle.net/2117/15097
DOI: 10.1016/j.actbio.2011.11.021
Versió de l'editor: http://www.sciencedirect.com/science/article/pii/S1742706111005228
Apareix a les col·leccions:Altres. Enviament des de DRAC
BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits. Articles de revista
Departament de Ciència dels Materials i Enginyeria Metal·lúrgica. Articles de revista
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