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Citació: Perut, F. [et al.]. Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response. "Acta biomaterialia", 10 Desembre 2010.
Títol: Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response
Autor: Baldini, Nicola; Perut, Francesca; Montufar Jiménez, Edgar Benjamin Veure Producció científica UPC; Ciapetti, Gabriela; Santin, Matteo; Salvage, J; Traykova, Tania; Planell Estany, Josep Anton Veure Producció científica UPC; Ginebra Molins, Maria Pau Veure Producció científica UPC
Data: 10-des-2010
Tipus de document: Article
Resum: Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. However, injectable formulations have so far only been obtained through the addition of relatively toxic surfactants. The present work describes the response of osteoblasts to a novel injectable foamed bone cement based on a composite formulation including the bioactive foaming agents soybean and gelatine. The foaming properties of both defatted soybean and gelatine gels were exploited to develop a self-hardening soy/gelatine/hydroxyapatite composite foam able to retain porosity upon injection. After setting, the foamed paste produced a calcium-deficient hydroxyapatite scaffold, showing good injectability and cohesion as well as interconnected porosity after injection. The intrinsic bioactivity of soybean and gelatine was shown to favour osteoblast adhesion and growth. These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery.
ISSN: 1742-7061
URI: http://hdl.handle.net/2117/11240
DOI: 10.1016/j.actbio.2010.12.012
Apareix a les col·leccions:BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits. Articles de revista
Departament de Ciència dels Materials i Enginyeria Metal·lúrgica. Articles de revista
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