• An optimized TOPS+ comparison method for enhanced TOPS models 

      Veeramalai, Mallika; Gilbert, David; Valiente Feruglio, Gabriel Alejandro (2010-03-17)
      Article
      Accés obert
      Background: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. ...
    • The extracellular N-terminal domain suffices to discriminate class C G Protein-Coupled Receptor subtypes from n-grams of their sequences 

      König, Caroline; Alquézar Mancho, René; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús (Institute of Electrical and Electronics Engineers (IEEE), 2015)
      Text en actes de congrés
      Accés obert
      The investigation of protein functionality often relies on the knowledge of crystal 3-D structure. This structure is not always known or easily unravelled, which is the case of eukaryotic cell membrane proteins such as G ...
    • Transcription factor binding site detection through position cross-mutual information variability analysis 

      Maynou Fernández, Joan; Vallverdú Ferrer, Montserrat; Clarià Sancho, Francesc; Gallardo Chacón, Joan Josep; Caminal Magrans, Pere; Perera Lluna, Alexandre (IEEE Press. Institute of Electrical and Electronics Engineers, 2009)
      Comunicació de congrés
      Accés obert
      Regulatory sequence detection is a fundamental challenge in computational biology. One key process in protein synthesis starts with the binding of the transcription factor to its binding site. Different sites can show ...