Exploració per autor "Céolin, René"
Ara es mostren els items 13-32 de 36
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Liquid-liquid miscibility gaps and hydrate formation in drug-water binary systems: Pressure-temperature phase diagram of lidocaine and pressure-temperature-composition phase diagram of the lidocaine-water system
Céolin, René; Barrio Casado, María del; Tamarit Mur, José Luis; Veglio, Néstor Raúl; Perrin, M.A.; Espeau, Ph. (2010-06-01)
Article
Accés restringit per política de l'editorialThe pressure–temperature (P–T) melting curve of lidocaine was determined (dP/dT¼3.56MPaK 1), and the lidocaine–water system was investigated as a function of temperature and pressure. The lidocaine–water system exhibits ... -
Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system
Rietveld, Ivo B.; Perrin, Jean-Claude; Toscani, Siro; Barrio Casado, María del; Nicolai, Beatrice; Tamarit Mur, José Luis; Céolin, René (2013-04)
Article
Accés restringit per política de l'editorialEMLA cream, a “eutectic mixture of local anesthetics”, was developed in the early 1980s by Astra Pharmaceutical Production. The mixture of anesthetics containing lidocaine, prilocaine, and water is liquid at room ... -
On the dimorphism of prednisolone: The topological pressure-temperature phase diagram involving forms I and II
Bauer, Michel; Lacoulonche, F.; Céolin, René; Barrio Casado, María del; Khichane, Imène; Robert, Benoit; Tamarit Mur, José Luis; Rietveld, Ivo B. (Elsevier, 2022-08-25)
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Accés obertThe dimorphism of the corticosteroid anti-inflammatory drug prednisolone has been investigated by the construction of a topological pressure–temperature phase diagram, using crystallographic and calorimetric data. The ... -
On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form
Allouchi, Hassan; Nicolai, Beatrice; Barrio Casado, María del; Céolin, René; Mahé, Nathalie; Tamarit Mur, José Luis; Do, Bernard; Rietveld, Ivo B. (2014-03-01)
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Accés restringit per política de l'editorialSolid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. ... -
Ordered and disordered solvates of C 60 and CBrCl 2 H
Ye, Jin; Barrio Casado, María del; Céolin, René; Qureshi, Navid; Negrier, Philippe; Rietveld, Ivo B.; Tamarit Mur, José Luis (2019-01-01)
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Accés obertThe formation of co-crystals is often unexpected; however, the Buckminster fullerene, for which many solvates are known,is an excellent system to study this tendency. In the present paper, C60 and CBrCl2H co-crystals have ... -
Orientational order in the stable buckminster fullerene solvate C60·2CBr2H2
Ye, Jin; Barrio Casado, María del; Negrier, Philippe; Qureshi, Navid; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-04-01)
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Accés obertCrystals of the solvate C60·2CBr2H2 (monoclinic C2/m), which is stable in air, were grown by slow evaporation of solutions of C60 in CBr2H2 at room temperature. The high enthalpy change for the complete desolvation process, ... -
Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate
Rietveld, Ivo B.; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René (2012-05-10)
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Accés restringit per política de l'editorialEnantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically active enantiomer. Although it is always possible to force separation, ... -
Pitfalls and feedback when constructing topological pressure-temperature phase diagrams
Céolin, René; Toscani, Siro; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis (2017-04-18)
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Accés obertThe stability hierarchy between different phases of a chemical compound can be accurately reproduced in a topological phase diagram. This type of phase diagrams may appear to be the result of simple extrapolations, however, ... -
Polymorphism of benzylthiouracil, an active pharmaceutical ingredient against hyperthyroidism
Rietveld, Ivo B.; Allouchi, Hassan; Barrio Casado, María del; Céolin, René; Tamarit Mur, José Luis (2021-04-01)
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Accés obertThe crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates of the two independent molecules of form I have been obtained for the first time. The ... -
Polymorphism of spironolactone: An unprecedented case of monotropy turning to enantiotropy with a huge difference in the melting temperatures
Rietveld, Ivo B.; Barrio Casado, María del; Lloveras Muntané, Pol Marcel; Céolin, René; Tamarit Mur, José Luis (2018-09-25)
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Accés obert -
Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
Barrio Casado, María del; Huguet, Jordi; Robert, B.; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-06-15)
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Accés obertUnderstanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however ... -
Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior
Barrio Casado, María del; Maccaroni, Elisabetta; Rietveld, Ivo B.; Macpezzi, Luciana; Masciocchi, Norberto; Céolin, René; Tamarit Mur, José Luis (2011-11-03)
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Accés restringit per política de l'editorialThe active pharmaceutical ingredient racemic benfluorex hydrochloride (benfluorex–HCl) has an interesting phase behavior due to an elusive solid–solid phase transition. The stability hierarchy between different phases is ... -
Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior
Perrin, Marc-Antoine; Bauer, Michel; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-05-20)
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Accés restringit per política de l'editorialCrystalline polymorphism occurs frequently in the solid state of active pharmaceutical ingredients, and this is problematic for the development of a suitable dose form. Rimonabant, an active pharmaceutical ingredient ... -
Solid-state properties and dehydration behavior of the active pharmaceutical ingredient potassium guaiacol-4-sulfonate
Mahé, Nathalie; Nicolai, Beatrice; Barrio Casado, María del; Perrin, Marc Antoine; Do, Bernard; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-05-20)
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Accés restringit per política de l'editorialPotassium guaiacolsulfonate is an active pharmaceutical ingredient that has been in use for more than a century, and it is still widely used in cough syrups. Nonetheless, no crystal structure has ever been determined to ... -
Stability hierarchy between Piracetam forms I, II, and III from experimental pressure–temperature diagrams and topological inferences
Toscani, Siro; Céolin, René; Ter Minassian, Leon; Barrio Casado, María del; Veglio, Néstor Raúl; Tamarit Mur, José Luis; Louër, Daniel; Rietveld, Ivo B. (2016-01-30)
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Accés obertThe trimorphism of the active pharmaceutical ingredient piracetam is a famous case of polymorphism that has been frequently revisited by many researchers. The phase relationships between forms I, II, and III were ambiguous ... -
The phase diagram of the API benzocaine and its highly persistent, metastable crystalline polymorphs
Rietveld, Ivo B.; Akiba, Hiroshi; Yamamuro, Osamu; Barrio Casado, María del; Céolin, René; Tamarit Mur, José Luis (Multidisciplinary Digital Publishing Institute (MDPI), 2023-05-20)
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Accés obertThe availability of sufficient amounts of form I of benzocaine has led to the investigation of its phase relationships with the other two existing forms, II and III, using adiabatic calorimetry, powder X-ray diffraction, ... -
The Pressure-temperature phase diagram of metacetamol and its comparison to the phase diagram of paracetamol
Barrio Casado, María del; Huguet, Judit; Rietveld, Ivo B.; Robert, Benoit; Céolin, René; Tamarit Mur, José Luis (2017-06-01)
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Accés obertUnderstanding the polymorphic behavior of active pharmaceutical ingredients is important for formulation purposes and regulatory reasons. Metacetamol is an isomer of paracetamol and it similarly exhibits polymorphism. In ... -
The relationship between orientational disorder and pressure: The case study of succinonitrile
Tamarit Mur, José Luis; Rietveld, Ivo B.; Barrio Casado, María del; Céolin, René (2014-12-25)
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Accés restringit per política de l'editorialPlastic phases can be considered as an intermediary state between the crystalline state and the liquid state, in which the molecules maintain their positions, but they exhibit orientational disorder. Whereas plastic phases ... -
The solid state of anti-inflammatory morniflumate diniflumate: A cocrystalline salt
Barrio Casado, María del; Céolin, René; Robert, Benoit; Allouchi, Hassan; Teulon, Jean-Marie; Guéchot, Christophe; Tamarit Mur, José Luis; Rietveld, Ivo B. (2021-12-15)
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Accés obertMorniflumate diniflumate, a molecular compound involving niflumic acid and its ß-morpholino ethyl ester (morniflumate) in the mole ratio 2:1, is found to crystallize in a triclinic P - 1 space group with a unit-cell volume ... -
Thermal expansion of L-ascorbic acid
Nicolaï, Béatrice; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2017-04-01)
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Accés obertThe specific volume of vitamin C has been investigated by X-ray powder diffraction as a function of temperature from 110¿K up to complete degradation around 440¿K. Its thermal expansion is relatively small in comparison ...