Exploració per autor "Céolin, René"
Ara es mostren els items 5-24 de 36
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Crystal structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
Mahe, N.; Nicolaï, B.; Allouchi, Hassan; Barrio Casado, María del; Do, Bernat; Céolin, René; Tamarit Mur, José Luis; Rietveld, Ivo B. (2013-02)
Article
Accés restringit per política de l'editorial3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert−Eaton myasthenic syndrome (LEMS). It is 3,4-diaminopyridine dihydrogen phosphate that has become the active ingredient of choice. As ... -
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
Teulon, Jean-Marie; Mahé, Nathalie; Do, Bernard; Nicolaï, Béatrice; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Ghéchot, Christophe (2012)
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Accés restringit per política de l'editorialAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ... -
Crystal structure of polymorph II and the pressure-temperature phase diagram of the dimorphic anesthetic butamben
Rietveld, Ivo B.; Barrio Casado, María del; Céolin, René; Tamarit Mur, José Luis (American Chemical Society, 2021-11-18)
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Accés obertThe crystal structure of the low-temperature form II of butamben has been solved in a P21/c space group very similar to that of form I. Form II possesses virtually the same packing as that of the high-temperature form I, ... -
Crystal structures and phase relationships of 2 polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A selective a-7 nicotinic receptor partial agonist
Robert, Benoit; Perrin, Marc-Antoine; Barrio Casado, María del; Tamarit Mur, José Luis; Coquerel, Gerard; Céolin, René; Rietveld, Ivo B. (2016-01)
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Accés obertTwo polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. ... -
Crystalline tetrazepam as a case study on the volume change on melting of molecular organic compounds
Rietveld, Ivo B.; Negrier, Philippe; Barrio Casado, María del; Allouchi, Hassan; Céolin, René; Tamarit Mur, José Luis (2021-01-25)
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Accés obertThe volume change on melting is a rarely studied quantity and it is not well understood even if it must reflect the changes in interaction between the solid and the liquid state. It is part of the solid-state information ... -
Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid
Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Do, Bernard; Céolin, René (2011-11-02)
Article
Accés restringit per política de l'editorialIn pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is often difficult to separate them. Even though this problem is likely as old ... -
Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties
Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Robert, Benoit; Guechot, C.; Teulon, J.M.; Rietveld, Ivo B. (2017-09-01)
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Accés obertThe pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L ... -
Experimental and topological determination of the pressure-temperature phase diagram of racemic etifoxine, a pharmaceutical ingredient with anxiolytic properties
Barrio Casado, María del; Allouchi, Hassan; Tamarit Mur, José Luis; Céolin, René; Berthon-Cédille, Laurence; Rietveld, Ivo B. (2019-12-18)
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Accés obertInformation about the solid-state properties of etifoxine has been lacking, even if the active pharmaceutical ingredient has been used for its anxiolytic properties for decennia. The crystal structure of the racemic compound ... -
Liquid-liquid miscibility gaps and hydrate formation in drug-water binary systems: Pressure-temperature phase diagram of lidocaine and pressure-temperature-composition phase diagram of the lidocaine-water system
Céolin, René; Barrio Casado, María del; Tamarit Mur, José Luis; Veglio, Néstor Raúl; Perrin, M.A.; Espeau, Ph. (2010-06-01)
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Accés restringit per política de l'editorialThe pressure–temperature (P–T) melting curve of lidocaine was determined (dP/dT¼3.56MPaK 1), and the lidocaine–water system was investigated as a function of temperature and pressure. The lidocaine–water system exhibits ... -
Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system
Rietveld, Ivo B.; Perrin, Jean-Claude; Toscani, Siro; Barrio Casado, María del; Nicolai, Beatrice; Tamarit Mur, José Luis; Céolin, René (2013-04)
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Accés restringit per política de l'editorialEMLA cream, a “eutectic mixture of local anesthetics”, was developed in the early 1980s by Astra Pharmaceutical Production. The mixture of anesthetics containing lidocaine, prilocaine, and water is liquid at room ... -
On the dimorphism of prednisolone: The topological pressure-temperature phase diagram involving forms I and II
Bauer, Michel; Lacoulonche, F.; Céolin, René; Barrio Casado, María del; Khichane, Imène; Robert, Benoit; Tamarit Mur, José Luis; Rietveld, Ivo B. (Elsevier, 2022-08-25)
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Accés obertThe dimorphism of the corticosteroid anti-inflammatory drug prednisolone has been investigated by the construction of a topological pressure–temperature phase diagram, using crystallographic and calorimetric data. The ... -
On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form
Allouchi, Hassan; Nicolai, Beatrice; Barrio Casado, María del; Céolin, René; Mahé, Nathalie; Tamarit Mur, José Luis; Do, Bernard; Rietveld, Ivo B. (2014-03-01)
Article
Accés restringit per política de l'editorialSolid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. ... -
Ordered and disordered solvates of C 60 and CBrCl 2 H
Ye, Jin; Barrio Casado, María del; Céolin, René; Qureshi, Navid; Negrier, Philippe; Rietveld, Ivo B.; Tamarit Mur, José Luis (2019-01-01)
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Accés obertThe formation of co-crystals is often unexpected; however, the Buckminster fullerene, for which many solvates are known,is an excellent system to study this tendency. In the present paper, C60 and CBrCl2H co-crystals have ... -
Orientational order in the stable buckminster fullerene solvate C60·2CBr2H2
Ye, Jin; Barrio Casado, María del; Negrier, Philippe; Qureshi, Navid; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-04-01)
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Accés obertCrystals of the solvate C60·2CBr2H2 (monoclinic C2/m), which is stable in air, were grown by slow evaporation of solutions of C60 in CBr2H2 at room temperature. The high enthalpy change for the complete desolvation process, ... -
Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate
Rietveld, Ivo B.; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René (2012-05-10)
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Accés restringit per política de l'editorialEnantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically active enantiomer. Although it is always possible to force separation, ... -
Pitfalls and feedback when constructing topological pressure-temperature phase diagrams
Céolin, René; Toscani, Siro; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis (2017-04-18)
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Accés obertThe stability hierarchy between different phases of a chemical compound can be accurately reproduced in a topological phase diagram. This type of phase diagrams may appear to be the result of simple extrapolations, however, ... -
Polymorphism of benzylthiouracil, an active pharmaceutical ingredient against hyperthyroidism
Rietveld, Ivo B.; Allouchi, Hassan; Barrio Casado, María del; Céolin, René; Tamarit Mur, José Luis (2021-04-01)
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Accés obertThe crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates of the two independent molecules of form I have been obtained for the first time. The ... -
Polymorphism of spironolactone: An unprecedented case of monotropy turning to enantiotropy with a huge difference in the melting temperatures
Rietveld, Ivo B.; Barrio Casado, María del; Lloveras Muntané, Pol Marcel; Céolin, René; Tamarit Mur, José Luis (2018-09-25)
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Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
Barrio Casado, María del; Huguet, Jordi; Robert, B.; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-06-15)
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Accés obertUnderstanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however ... -
Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior
Barrio Casado, María del; Maccaroni, Elisabetta; Rietveld, Ivo B.; Macpezzi, Luciana; Masciocchi, Norberto; Céolin, René; Tamarit Mur, José Luis (2011-11-03)
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Accés restringit per política de l'editorialThe active pharmaceutical ingredient racemic benfluorex hydrochloride (benfluorex–HCl) has an interesting phase behavior due to an elusive solid–solid phase transition. The stability hierarchy between different phases is ...