• Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics 

      Nyga, Agata; Muñoz Romero, José; Dercksen, Suze; Fornabaio, Giulia; Uroz, Marina; Trepat Guixer, Xavier; Baum, Buzz; Matthews, Helen K.; Conte, Vito (2021-10-13)
      Article
      Accés obert
      The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor development. Here, we ask how the uniform activation oncogene RAS affects the morphology and tissue mechanics in a ...
    • Robust mechanisms of ventral furrow invagination require the combination of cellular shape changes 

      Conte, Vito; Muñoz Romero, José; Baum, Buzz; Miodownik, M. (2009-05)
      Article
      Accés obert
      Ventral furrow formation in Drosophila is the first large-scale morphogenetic movement during the life of the embryo, and is driven by co-ordinated changes in the shape of individual epithelial cells within the cellular ...
    • Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex 

      Khalilgharibi, Nargess; Fouchard, Jonathan; Asadipour, Nina; Barrientos, Ricardo; Duda, Maria; Bonfanti, Alessandra; Yonis, Amina; Harris, Andrew; Mosaffa, Payman; Fujita, Yasuyuki; Kabla, Alexandre; Mao, Yanlan; Baum, Buzz; Muñoz Romero, José; Miodownik, Mark; Charras, Guillaume (2019-01-01)
      Article
      Accés obert
      Epithelial monolayers are one-cell thick tissue sheets that separate internal and external environments. As part of their function, they have to withstand extrinsic mechanical stresses applied at high strain rates. However, ...