• Structural studies of AT-rich DNA 

      Acosta Reyes, Francisco Javier (Universitat Politècnica de Catalunya, 2016-05-26)
      Tesi
      Accés obert
      Non-coding DNA is rich in adenines and thymines. Their unique properties, such as high polymorphism, flexibility, transitional states that lead to DNA hairpin formation and the possibility to adopt either Watson-Crick or ...
    • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

      Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
      Article
      Accés obert
      The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...
    • The influence of Ni2+ and other ions on the trigonal structure of DNA 

      Acosta Reyes, Francisco Javier; Pagan, Mireia; Fonfría-Subirós, Elsa; Saperas Plana, Núria; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (Wiley, 2021-04-13)
      Article
      Accés obert
      We present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form ...
    • Two high-mobility group box domains act together to underwind and kink DNA. 

      Sánchez Giraldo, Raquel; Acosta Reyes, Francisco Javier; Malarkey, Christopher S.; Saperas Plana, Núria; Churchill, Mair E. A.; Campos López, Josefina de Lourdes (2015-07-02)
      Article
      Accés obert
      High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...