Exploració per autor "Benítez Iglesias, Raúl"
Ara es mostren els items 46-50 de 50
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The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
Herraiz Martínez, Adela; Llach Martínez, Anna; Tarifa Lora, Carmen; Gandía, Jorge; Jiménez Sábado, Verónica; Lozano Velasco, Estefanía; Serra Pascual, Selma A.; Vallmitjana Lees, Alexander; Vázquez Ruiz de Castroviejo, Eduardo; Benítez Iglesias, Raúl (2019-03-01)
Article
Accés obertAims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ... -
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
Sun, Bo; Wei, Jinhong; Zhong, Xiaowei; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl (2018-07-09)
Article
Accés obertSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ... -
Translational diagnostics: an in-house pipeline to validate genetic variants in children with undiagnosed and rare diseases
Pijuan Casas, Jordi; Rodríguez Sanz, Maica; Cortez, Carolina; Altimir, A; Afonso Rodriguez, Carmen Nieves; Benítez Iglesias, Raúl; do Nascimento, Anderson Thiago (2021-01-13)
Article
Accés obertDiagnosis is essential for the management and treatment of patients with rare diseases. In a group of patients, the genetic study identifies variants of uncertain significance or inconsistent with the phenotype; therefore, ... -
TS-CNN: a three-tier self-interpretable CNN for multi-region medical image classification
Ashwath, V. A.; Okkath Krishnanunni, Sikha; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2023-07-31)
Article
Accés obertMedical image classification is critical, where reliability and transparency are crucial for the safe and accurate diagnosis of diseases. Deep Convolutional Neural Networks (DCNNs) are widely used in medical image ... -
ß2-adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co-activation of ryanodine receptor clusters
Nolla Colomer, Carme; Casabella Ramón, Sergi; Jiménez Sábado, Verónica; Vallmitjana Lees, Alexander; Tarifa Lora, Carmen; Herraiz Martínez, Adela; Montiel Dacosta, José Antonio; Cinca Cuscullola, Juan Maria; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2022-04-13)
Article
Accés obertAims It is unknown how ß-adrenergic stimulation affects calcium dynamics in individual RyR2 clusters and leads to the induction of spontaneous calcium waves. To address this, we analysed spontaneous calcium release ...