Exploració per autor "Benítez Iglesias, Raúl"Més informacióMés informació

Ara es mostren els items 27-46 de 50

    • Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes 

      Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
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      The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ...

    • MedicalSeg: a medical GUI application for image segmentation management 

      Mata Miquel, Cristian; Munuera, Josep; Lalande, Alain; Ochoa Ruíz, Gilberto; Benítez Iglesias, Raúl (Multidisciplinary Digital Publishing Institute (MDPI), 2022-06-08)
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      In the field of medical imaging, the division of an image into meaningful structures using image segmentation is an essential step for pre-processing analysis. Many studies have been carried out to solve the general problem ...

    • Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model 

      Civera Tregón, Azahara; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2021-05)
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      Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. ...

    • Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease 

      Cantarero, Lara; Juárez Escoto, Elena; Civera Tregón, Azahara; Rodríguez Sanz, María; Roldán, Mónica; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2020-11-06)
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      Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ...

    • Motor adaptation as a greedy optimization of error and effort 

      Emken, Jeremy L.; Benítez Iglesias, Raúl; Sideris, Athanasios; Bobrow, James E.; Reinkensmeyer, David J. (The American Physiological Society, 2007-03-31)
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      Accés restringit per política de l'editorial
      thought of as a process in which the nervous system learns to anticipate the environmental forces to eliminate kinematic error. Here we show that motor adaptation can more generally be modeled as a process in which the ...

    • Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes 

      Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Barriga, Montserrat; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2013)
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      Accés restringit per política de l'editorial
      We present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ...

    • Multiscale image analysis of calcium dynamics in cardiac myocytes 

      Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl (2022-06-01)
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      Cardiac myocytes are the muscle cells that build up heart tissue and provide the mechanical action to pump blood by synchronously contracting at every heartbeat. Heart muscle contraction is regulated by intracellular calcium ...

    • Phase-field models in interfacial pattern formation out of equilibrium 

      González Cinca, Ricardo; Folch, R.; Benítez Iglesias, Raúl; Ramírez de la Piscina Millán, Laureano; Casademunt, Jaume; Hernández-Machado, A. (NOVA, 2004-06)
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    • Phase-field study of transient stages and fluctuations in solidification 

      Benítez Iglesias, Raúl (Universitat Politècnica de Catalunya, 2005-01-27)
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      L'estudi de la formació de microstructures en processos de solidificació té importants aplicacions científiques i tecnològiques. L'aparició d'aquestes estructures determina les propietats elèctriques i mecàniques del ...

    • Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice 

      Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
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      Accés restringit per política de l'editorial
      Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ...

    • Pitx2c deficiency confers cellular electrophysiological hallmarks of atrial fibrillation to isolated atrial myocytes 

      Tarifa Lora, Carmen; Serra, Selma A.; Herraiz Martínez, Adela; Lozano Velasco, Estefanía; Benítez Iglesias, Raúl; Aránega Jiménez, Amelia; Franco Jaime, Diego; Hove Madsen, Leif (Elsevier, 2023-06-01)
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      Aims Atrial fibrillation (AF) has been associated with altered expression of the transcription factor Pitx2c and a high incidence of calcium release-induced afterdepolarizations. However, the relationship between Pitx2c ...

    • Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes 

      Llacher Alsina, Anna Pilar; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Montiel Dacosta, José Antonio; Cinca Cusculluela, Juan (2016-01-01)
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      © 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) ...

    • Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans 

      Zhong, Xiaowei; Vallmitjana Lees, Alexander; Sun, Bo; Xiao, Zhichao; Benítez Iglesias, Raúl (2018-01-15)
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    • Robust unsupervised detection of action potentials with probabilistic models 

      Benítez Iglesias, Raúl; Nenadic, Zoran (Institute of Electrical and Electronics Engineers, 2008-04-30)
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      Accés restringit per política de l'editorial
      We develop a robust and fully unsupervised algorithm for the detection of action potentials from extracellularly recorded data. Using the continuous wavelet transform allied to probabilistic mixture models and Bayesian ...

    • RyR2 serine-2030 PKA site governs Ca2+release termination and Ca2+alternans 

      Wei, Jinhong; Guo, Wenting; Wang, Ruiwu; Estillore, John Paul; Belke, Darrell; Chen, Yong-Xiang; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S.R. Wayne (2023-01-20)
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      Background: PKA (protein kinase A)–mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively studied for decades, but the physiological significance of PKA phosphorylation of RyR2 remains ...

    • Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP 

      Unzueta, Ugutz; Roldán Molina, Mónica; Pesarrodona, Mireia; Benítez Iglesias, Raúl; Sanchez Chardi, Alejandro; Conchillo, Oscar; Mangues, Ramón; Villaverde, Antonio; Vazquez Gómez, Esther (Elsevier, 2020-02-03)
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      Fluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been ...

    • Semi-automatic GUI platform to characterize brain development in preterm children using ultrasound images 

      Rabanaque, David; Regalado, Maria; Benítez Iglesias, Raúl; Rabanaque Rodríguez, Sonia; Agut, Thais; Carreras, Núria; Mata Miquel, Cristian (2023-07-15)
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      The third trimester of pregnancy is the most critical period for human brain development, during which significant changes occur in the morphology of the brain. The development of sulci and gyri allows for a considerable ...

    • Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes 

      Tarifa Lora, Carmen; Vallmitjana Lees, Alexander; Jiménez Sábado, Verónica; Marchena Angos, Miquel; Llach, Anna; Herraiz Martínez, Adela; Nolla Colomer, Carme; Ginel Iglesias, Antonino; Montiel Dacosta, José Antonio; Ciruela, Francisco; Echebarría Domínguez, Blas; Benítez Iglesias, Raúl; Cinca Cuscullola, Juan Maria; Hove-Madsen, Leif (Elsevier, 2023-01)
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      Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor ...

    • Stochastic Phase-Field simulations of symmetric alloy solidification 

      Benítez Iglesias, Raúl; Ramírez de la Piscina Millán, Laureano (2004-09)
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      We study initial transient stages in directional solidification by means of a non-variational phase field model with fluctuations. This model applies for the symmetric solidification of dilute binary solutions and does not ...

    • The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis 

      Herraiz Martínez, Adela; Llach Martínez, Anna; Tarifa Lora, Carmen; Gandía, Jorge; Jiménez Sábado, Verónica; Lozano Velasco, Estefanía; Serra Pascual, Selma A.; Vallmitjana Lees, Alexander; Vázquez Ruiz de Castroviejo, Eduardo; Benítez Iglesias, Raúl (2019-03-01)
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      Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ...