Background – A composite endpoint is often used as the primary endpoint to assess the efficacy of a new treatment in randomized clinical trials (RCT). In cardiovascular trials, the often rare event of the relevant primary ...

Background: The incubation period of an infectious disease is defined as the elapsed time between the exposure to the pathogen and the onset of symptoms. Although both the mRNA-based and the adenoviral vector-based vaccines ...

The choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more ...

A doubly censoring scheme occurs when the lifetimes T being measured, from a well-known time origin, are exactly observed within a window [L,R] of observational time and are otherwise censored either from above (right-censored ...

When comparing two treatment groups in a time-to-event analysis, it is common to use a composite event consisting of two or more distinct outcomes. The goal of this paper is to develop a statistical methodology to derive ...

A key assumption for the application of methods concerning censored data is that the random nature of the censoring mechanism should be ignorable when making likelihood-based inferences. The constant-sum property is an ...

Ressenya sobre la recerca actual en estadística a Catalunya: resultats del grup d'investigació català "The GRASS Group (Grup de Recerca en Anàlisis eStadística de la Supervivència)"

Competing risks data usually arises in studies in which the failure of an individual may be classified into one of k (k > 1) mutually exclusive causes of failure. When competing risks are present, there are two main ...

Although composite endpoints (CE) are common in clinical trials, the impact of the relationship between the components of a binary CE on the sample size requirement (SSR) has not been addressed. We performed a computational ...