Este artículo es una transcripción de las conferencias dictadas en la mesa organizada en el 4º Congreso Galego de Estatistica y Investigación de Operacions que tuvo lugar en Santiago de Compostela en noviembre de 1999. Los ...

Background: Modelling the course of a disease regarding severe events and identifying prognostic factors is of great clinical relevance. Multistate models (MSM) can be used to describe diseases or processes that change ...

The hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over time although this assumption often does not ...

Background – A composite endpoint is often used as the primary endpoint to assess the efficacy of a new treatment in randomized clinical trials (RCT). In cardiovascular trials, the often rare event of the relevant primary ...

Background: The incubation period of an infectious disease is defined as the elapsed time between the exposure to the pathogen and the onset of symptoms. Although both the mRNA-based and the adenoviral vector-based vaccines ...

The choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more ...

A doubly censoring scheme occurs when the lifetimes T being measured, from a well-known time origin, are exactly observed within a window [L,R] of observational time and are otherwise censored either from above (right-censored ...