Exploració per autor "Pérez González, Juan Jesús"
Ara es mostren els items 31-50 de 57
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Identification of a novel inhibitory allosteric site of MAP kinases
Gomez-Gutierrez, Patricia; Campos Muelas, Pedro Manuel; Vega, Miguel; Pérez González, Juan Jesús (2016-11-29)
Article
Accés obertIn the present study, we report the discovery of a novel allosteric inhibitory site for p38a, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the ... -
Identification of potential small molecule binding pockets in p38a MAP kinase
Gómez Gutierrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (2017-10-23)
Article
Accés obertGiven the essential role played by protein kinases in regulating cellular pathways, their dysregulation can result in the onset and/or progression of various human diseases. Structural analysis of diverse protein kinases ... -
Jornada EIT Urban Mobility
Pérez González, Juan Jesús; Sierra, Daniel; Sayrol Clols, Elisa (2021-03-23)
Audiovisual
Accés obert -
Mercury-induced dark-state instability and photobleaching alterations of the visual G-protein coupled receptor rhodopsin
Morillo Cazorla, Margarita; Toledo Gonzalez, Darwin; Pérez González, Juan Jesús; Ramon Portés, Eva; Garriga Solé, Pere (2014-07-01)
Article
Accés restringit per política de l'editorialMercuric compounds were previously shown to affect the visual phototransduction cascade, and this could result in vision impairment. We have analyzed the effect of mercuric chloride on the structure and stability of the ... -
Molecular determinants for the activation/inhibition of bak protein by BH3 peptides
Vila Julià, Guillem; Granadino, Jose Manuel; Pérez González, Juan Jesús; Rubio Martínez, Jaime (2020-03-23)
Article
Accés obertApoptosis is a key cell death pathway in mammalian cells. Understanding this process and its regulation has been a subject of study in the last three decades. Members of the Bcl-2 family of proteins are involved in the ... -
Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study
Lupala, Cecylia Severin; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2013-06-13)
Article
Accés obertAbstract: Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition ... -
Molecular features characterizing non-peptide selectivity to the human B1 and B2 bradykinin receptors
Rasaeifar, B.; Lupala, C.S.; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2019-01-01)
Article
Accés restringit per política de l'editorialBradykinin is produced in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases. Actions of this peptide are mediated through two different G-protein coupled receptors, named B1 and B2 ... -
Molecular features of non-selective small molecule antagonists of the Bradykinin receptors
Rasaeifar, Bahareh; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2020-09-21)
Article
Accés obertAngiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of ... -
Molecular polarization potential as a molecular descriptor to predict biological activity of dioxins and dibenzofurans
Roset Calzada, María Lourdes; Pérez González, Juan Jesús (2016-07-06)
Article
Accés restringit per política de l'editorialMolecular interaction potential (MIP) maps are a powerful tool to develop structure-activity relationships of a series of compounds. In the present study we have studied the effect of molecular polarization on the description ... -
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations
Herrera Hernández, María Guadalupe; Razzaghi, Neda; Fernández González, Pol; Bosch Presegue, Laia; Vila i Julià, Guillem; Pérez González, Juan Jesús; Garriga Solé, Pere (Springer Nature, 2022-01-01)
Article
Accés obertMutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently ... -
New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding
Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-08-17)
Article
Accés obertMembers of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding
Pérez González, Juan Jesús; Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia (2016-07-21)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding.
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-07-26)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-01-20)
Article
Accés obertBradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases, provoking vasodilatation and increased vascular permeability among other ... -
On-line quality assurance of study programmes: EQUASP approach
Suqarzoni, Alfredo; Pérez González, Juan Jesús; Mager, Vladimir (2016-04-05)
Article
Accés obertThe description of the EQUASP model for quality assurance of study programmes, developed in framework of a TEMPUS project, is introduced. The introduction section contains brief information on the concept of quality and ... -
Randomized tree construction algorithm to explore energy landscapes
Jaillet, Leonard Georges; Corcho Sánchez, Francisco José; Pérez González, Juan Jesús; Cortés, Juan (2011-12)
Article
Accés obertWe report in the present work a new method for exploring conformational energy landscapes. The method, called T-RRT, combines ideas from statistical physics and robot path planning algorithms. A search tree is constructed ... -
Rational design of new class of BH3-mimetics as inhibitors of the Bcl-X(L) protein
Pinto Manresa, Marta; Orzaez, Maria del Mar; Delgado-Soler, L.; Pérez González, Juan Jesús; Rubio Martinez, Jaime (2011-06)
Article
Accés obertThe Bcl-2 family of proteins plays an important role in the intrinsic pathway of cell apoptosis. Overexpression of prosurvival members of this family of proteins is often associated with the development of many types of ... -
Social responsibility as a transversal competence of graduates
Pérez González, Juan Jesús (2016)
Text en actes de congrés
Accés obertPaper purpose: The aim of the present communication is to propose a procedure to assess the level of competence achieved by graduates. Design/methodology/theoretical approach: We propose to use a quality assurance ... -
Structural characterization of a zinc high-affinity binding site in rhodopsin
Darwin, Toledo; Cordomí Montoya, Arnau; Proietti, Maria Grazia; Maurizio, Benfatto; Valle Mendoza, Luis Javier del; Pérez González, Juan Jesús; Garriga Solé, Pere; Sepulcre Sánchez, Francesc (2009-02)
Article
Accés restringit per política de l'editorial -
Structural study of a new HIV-1 entry inhibitor and interaction with the HIV-1 fusion peptide in dodecylphosphocholine micelles
Pérez González, Juan Jesús; Pérez, Yolanda; Gómara, Maria José; Yuste, Eloísa; Gómez Gutierrez, Patricia; Haro, Isabel (2017-07-03)
Article
Accés obertPrevious studies support the hypothesis that the envelope GB virus C (GBV-C) E1 protein interferes the HIV-1 entry and that a peptide, derived from the region 139-156 of this protein, has been defined as a novel HIV-1 entry ...