Exploració per autor "Llach, Anna"

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    • Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity 

      Jiménez Sábado, Verónica; Casabella Ramón, Sergi; Llach, Anna; Gich, Ignasi; Casellas Casanova, Sandra; Ciruela, Francisco; Chen, S.R. Wayne; Guerra Ramos, José Mª; Ginel Iglesias, Antonino; Benítez Iglesias, Raúl; Cinca, Juan; Tarifa Lora, Carmen; Hove-Madsen, Leif (Elsevier, 2023-02-01)
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      Aims Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because ß-blockers are expected to ...

    • Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations 

      Riveras Torres, Jose; Calvo, Conrado J.; Llach, Anna; Gúzman Martínez, Gabriela; Caballero, Ricardo; González Gómez, Cristina; Jiménez Borreguero, Luís J.; Guadix, Juan A.; Osorio, Fernando G.; López Otín, Carlos; Herraiz Martínez, Adela; Cabello, Nuria; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Gordon, Leslie B. (2016-11-15)
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      Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ...

    • Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes 

      Llach, Anna; Molina, Cristina E.; Álvarez Lacalle, Enrique; Tort, Lluis; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2011-08-29)
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      Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an ...

    • Identification of intracellular calcium dynamics in stimulated cardiomyocytes 

      Vallmitjana Lees, Alexander; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Álvarez Lacalle, Enrique; Hove-Madsen, Leif; Benítez Iglesias, Raúl (IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
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      We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ...

    • Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes 

      Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
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      The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ...

    • Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes 

      Tarifa Lora, Carmen; Vallmitjana Lees, Alexander; Jiménez Sábado, Verónica; Marchena Angos, Miquel; Llach, Anna; Herraiz Martínez, Adela; Nolla Colomer, Carme; Ginel Iglesias, Antonino; Montiel Dacosta, José Antonio; Ciruela, Francisco; Echebarría Domínguez, Blas; Benítez Iglesias, Raúl; Cinca Cuscullola, Juan Maria; Hove-Madsen, Leif (Elsevier, 2023-01)
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      Accés obert
      Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor ...