Ara es mostren els items 1-17 de 17

    • A deep learning-based method for uncovering GPCR ligand-induced conformational states using interpretability techniques 

      Gutiérrez Mondragón, Mario Alberto; König, Caroline; Vellido Alcacena, Alfredo (Springer, 2022)
      Text en actes de congrés
      Accés obert
      There is increasing interest in the development of tools for investigating the protein ligand space. Understanding the underlying mechanisms of G protein-coupled receptors (GPCR) in the ligand-binding process is of particular ...
    • A model of large-scale proteome evolution 

      Vicente Solé, Ricardo; Pastor Satorras, Romualdo; Smith, E; Kepler, T .B. (2002-03)
      Article
      Accés obert
      The next step in the understanding of the genome organization, after the determination of complete sequences, involves proteomics. The proteome includes the whole set of protein-protein interactions, and two recent independent ...
    • An application of Dynamic Programming to Spectra Coding for PIPI 

      Martos Berruezo, Alejandro (Universitat Politècnica de Catalunya, 2020-05-21)
      Treball Final de Grau
      Accés obert
      Realitzat a/amb:   Hong Kong University of Science and Technology
      PIPI és un software per identificar péptids amb un nombre il·limitat de modificacions post-traducció (PTM). La identificació resulta intratable si es volen considerar tots els tipus posibles de PTM. La codificació dels ...
    • Analysis of incomplete gene expression dataset through protein-protein interaction information 

      Massanet Vila, Raimon; Padró Capmany, Teresa; Cardús, Anna; Badimón, Lina; Caminal Magrans, Pere; Perera Lluna, Alexandre (2011)
      Text en actes de congrés
      Accés restringit per política de l'editorial
      This paper shows a graph based method to analyze proteomic expression data. The method allows the prediction of the expression of genes not measured by the gene expression technology based on the local connectivity properties ...
    • Complex networks in genomics and proteomics 

      Vicente Solé, Ricardo; Pastor Satorras, Romualdo (Wiley-VCH, 2003)
      Capítol de llibre
      Accés restringit per política de l'editorial
      Complex interacting networks are observed in systems from such diverse areas as physics, biology, economics, ecology, and computer science. For example, economic or social interactions often organize themselves in complex ...
    • Development of a protein quantification algorithm for data analysis in the field of proteomics 

      Llovet Soto, Ariadna (Universitat Politècnica de Catalunya, 2014-01-22)
      Projecte/Treball Final de Carrera
      Accés obert
      Realitzat a/amb:   University of Washington
      Desenvolupament d'un algorisme de quantificació proteòmica i d'un mòdul web per a la seva utilització. L'objectiu de la quantificació proteòmica és obtenir informació quantitativa sobre els pèptids que es troben en una ...
    • Development of a web interface for managing scientific applications in the field of proteomics 

      Quilez Cuenca, Oriol (Universitat Politècnica de Catalunya, 2014-11-01)
      Treball Final de Grau
      Accés restringit per acord de confidencialitat
      Realitzat a/amb:   University of Washington
    • Evolving protein interaction networks through gene duplication 

      Pastor Satorras, Romualdo; Smith, E; Solé, Ricard Vicenç (2003-05-21)
      Article
      Accés obert
      The topology of the proteome map revealed by recent large-scale hybridization methods has shown that the distribution of protein–protein interactions is highly heterogeneous, with many proteins having few edges while a few ...
    • Exploratory visualization of misclassified GPCRs from their transformed unaligned sequences using manifold learning techniques 

      Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; König, Caroline; Alquézar Mancho, René; Giraldo Arjonilla, Jesús (Copicentro Granada, 2014)
      Text en actes de congrés
      Accés obert
      Class C G-protein-coupled receptors (GPCRs) are cell membrane proteins of great relevance to biology and pharmacology. Previous research has revealed an upper boundary on the accuracy that can be achieved in their ...
    • Finding class C GPCR subtype-discriminating n-grams through feature selection 

      König, Caroline; Alquézar Mancho, René; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús (Springer International Publishing, 2014)
      Text en actes de congrés
      Accés obert
      G protein-coupled receptors (GPCRs) are a large and heterogeneous superfamily of receptors that are key cell players for their role as extracellular signal transmitters. Class C GPCRs, in particular, are of great interest ...
    • Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors 

      Koenig, Caroline; Cárdenas Domíınguez, Martha Ivón; Giraldo Arjonilla, Jesús; Alquézar Mancho, René; Vellido Alcacena, Alfredo (2015-09-29)
      Article
      Accés obert
      Background: The characterization of proteins in families and subfamilies, at different levels, entails the definition and use of class labels. When the adscription of a protein to a family is uncertain, or even wrong, this ...
    • Layer-wise relevance analysis for motif recognition in the activation pathway of the ß2-adrenergic GPCR receptor 

      Gutiérrez Mondragón, Mario Alberto; König, Caroline; Vellido Alcacena, Alfredo (2023-01-06)
      Article
      Accés obert
      G-protein-coupled receptors (GPCRs) are cell membrane proteins of relevance as therapeutic targets, and are associated to the development of treatments for illnesses such as diabetes, Alzheimer’s, or even cancer. Therefore, ...
    • Misclassification of class C G-protein-coupled receptors as a label noise problem 

      König, Caroline; Vellido Alcacena, Alfredo; Alquézar Mancho, René; Giraldo Arjonilla, Jesús (2014)
      Comunicació de congrés
      Accés obert
      G-Protein-Coupled Receptors (GPCRs) are cell membrane proteins of relevance to biology and pharmacology. Their supervised classification in subtypes is hampered by label noise, which stems from a combination of expert ...
    • Transcriptome and proteome profiling reveals complex adaptations of Candida parapsilosis cells assimilating hydroxyaromatic carbon sources 

      Cillingová, Andrea; Tóth, Renáta; Mojáková, Anna; Zeman, Igor; Vrzoňová, Romana; Mutti, Giacomo; Gabaldón, Toni (Public Library of Science (PLOS), 2022-03)
      Article
      Accés obert
      Many fungal species utilize hydroxyderivatives of benzene and benzoic acid as carbon sources. The yeast Candida parapsilosis metabolizes these compounds via the 3-oxoadipate and gentisate pathways, whose components are ...
    • Use of Gene Ontology semantic information in protein interaction data visualization 

      Massanet Vila, Raimon; Caminal Magrans, Pere; Perera Lluna, Alexandre (IEEE Press. Institute of Electrical and Electronics Engineers, 2008)
      Text en actes de congrés
      Accés obert
      The Gene Ontology project is an effort to structure knowledge on biological products and processes by adding semantic information to them. This is done in a systematic way so that this additional information can be ...
    • Using machine learning tools for protein database biocuration assistance 

      König, Caroline; Shaim, Ilmira; Vellido Alcacena, Alfredo; Romero Merino, Enrique; Alquézar Mancho, René; Giraldo Arjonilla, Jesús (Nature, 2018-07-05)
      Article
      Accés obert
      Biocuration in the omics sciences has become paramount, as research in these fields rapidly evolves towards increasingly data-dependent models. As a result, the management of web-accessible publicly-available databases ...
    • Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences 

      Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús (Institute of Electrical and Electronics Engineers (IEEE), 2014)
      Text en actes de congrés
      Accés restringit per política de l'editorial
      This brief paper addresses the problem of visually assessing the natural discriminability of the different subtypes that characterize class C G-Protein-Coupled Receptors, which are membrane proteins of interest in pharmacology, ...