Exploració per tema "Peptides"
Ara es mostren els items 1-20 de 92
-
A computational study of Neuromedin B
(2011-09-15)
Article
Accés restringit per política de l'editorialA methodological study has been undertaken to assess the conformational profile of Neuromedin B (NMB) using classical molecular dynamics simulations (MD) and replica exchange molecular dynamics (REMD) simulations under ... -
A novel peptide-based platform for the dual presentation of biologically-active peptide motifs on biomaterials
(2014-03-27)
Article
Accés restringit per política de l'editorialBiofunctionalization of metallic materials with cell adhesive molecules derived from the extracellular matrix is a feasible approach to improve cell–material interactions and enhance the biointegration of implant materials ... -
A protocol for the design of protein and peptide nanostructure self-assemblies exploiting synthetic amino acids
(2017)
Capítol de llibre
Accés obertIn recent years there has been increasing interest in nanostructure design based on the self-assembly properties of proteins and polymers. Nanodesign requires the ability to predictably manipulate the properties of the ... -
A single-residue substitution inhibits fibrillization of Ala-based pentapeptides. A spectroscopic and molecular dynamics investigation
(2014-01-01)
Article
Accés obertThe aggregation properties of two Ala-based pentapeptides were investigated by spectroscopic techniques and molecular dynamics (MD) simulations. The two peptides, both functionalized at the N-terminus with a pyrenyl group, ... -
A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics
(American Chemical Society, 2023-01-01)
Article
Accés restringit per política de l'editorialBak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ... -
A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides
(2021-01-25)
Article
Accés obert
Realitzat a/amb: Universitat de Barcelona / Institut de Bioenginyeria de CatalunyaA novel and versatile toolkit approach for the functionalization of biomaterials of different nature is described. This methodology is based on the solid-phase conjugation of specific anchoring units onto a resin-bound ... -
Aggregation propensity of therapeutic fibrin-homing pentapeptides: Insights from experiments and molecular dynamics simulations
(Royal Society of Chemistry, 2020-11-28)
Article
Accés obertCREKA (Cys–Arg–Glu–Lys–Ala) and its engineered analogue CRMeEKA, in which Glu has been replaced by N-methyl-Glu to provide resistance against proteolysis, are emerging pentapeptides that were specifically designed to bind ... -
All-in-one trifunctional strategy: A cell adhesive, bacteriostatic and bactericidal coating for titanium implants
(2018-09-01)
Article
Accés obertStrategies to inhibit initial bacterial adhesion are extremely important to prevent infection on biomaterial surfaces. However, the simultaneous attraction of desired eukaryotic cells remains a challenge for successful ... -
Amphipathic solvation of indole: implications for the role of tryptophan in membrane proteins
(2015-05-14)
Article
Accés obertThe microscopic structure of the tryptophan side chain, indole, in an amphiphilic environment has been investigated using a combination of neutron diffraction measurements and simulations in solution. The results show that ... -
Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)
(2013-12-02)
Article
Accés restringit per política de l'editorialPeptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes ... -
Amyloid-like fibrils from a diphenylalanine capped with an aromatic fluorenyl
(2018-11-19)
Article
Accés obertThe self-assembly behavior of a diphenylalanine amphiphile blocked at the C-terminus with a 9-fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate (TFA) anion, TFA·FF-OFm, has been examined. At ... -
Antimicrobial peptides: Powerful biorecognition elements to detect bacteria in biosensing technologies
(2018-01-01)
Article
Accés obertBacterial infections represent a serious threat in modern medicine. In particular, biofilm treatment in clinical settings is challenging, as biofilms are very resistant to conventional antibiotic therapy and may spread ... -
Assessment of the conformational profile of bombesin by computational methods
(2020-07-20)
Article
Accés obertIn the present work, the results of a computational study aimed at assessing the conformational profile of bombesin are reported. The conformational space of the peptide was sampled by means of a 4 µs accelerated molecular ... -
Assessment of the sampling performance of multiple-copy dynamics versus a unique trajectory
(2016-10-01)
Article
Accés restringit per política de l'editorialThe goal of the present study is to ascertain the differential performance of a long molecular dynamics trajectory versus several shorter ones starting from different points in the phase space and covering the same sampling ... -
avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating
(2016-06-13)
Article
Accés obert
Realitzat a/amb: Technische Universität MünchenEngineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review ... -
Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avß3-selective cyclic RGD peptides
(2013)
Article
Accés restringit per política de l'editorialIt is well known that functionalization of surfaces with cell adhesive peptides mimicking the integrin binding motif of extracellular matrix proteins is a feasible approach to improve osseointegration of implant materials. ... -
Biofunctionalization of patterned PLLA surfaces with RGD, REDV and YIGSR peptides to promote endothelial cells adhesion and migration
(2016)
Comunicació de congrés
Accés obert
Realitzat a/amb: Universität des SaarlandesAngioplasty and stent implantation open the blocked artery and restore proper blood flow after atherosclerosis disease. Despite their utility, intracoronary stents induce two types of complications: in-stent restenosis and ... -
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes a5ß1 and avß6: conformational control through flanking amino acids
(2013)
Article
Accés restringit per política de l'editorialIntegrins are the major class of cell adhesion proteins. Their interaction with different ligands of the extracellular matrix is diverse. To get more insight into these interactions, artificial ligands endowed with a ... -
Co-localization of RGD and PHSRN peptides on titanium to guide stem cell behaviour and enhance Implant osteointegration
(2015)
Comunicació de congrés
Accés obert -
Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor
(Wiley Online Library, 2015-11-10)
Article
Accés obertThe modulation of protein–protein interactions (PPIs) is emerging as a highly promising tool to fight diseases. However, whereas an increasing number of compounds are able to disrupt peptide-mediated PPIs efficiently, the ...