• Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes 

      Hiess, Florian; Vallmitjana Lees, Alexander; Wang, Ruiwu; Cheng, Hongqiang; ter Keurs, Henk; Chen, Ju; Hove-Madsen, Leif; Benítez Iglesias, Raúl; Chen, S. R. Wayne (2015-08-14)
      Article
      Accés obert
      The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ...
    • Increased Ca2+ transient underlies RyR2-related left ventricular noncompaction 

      Ni, Mingke; Li, Yanhui; Wei, Jinhong; Song, Zhenpeng; Wang, Hui; Yao, Jinjing; Chen, Yong-Xiang; Belke, Darrell; Estillore, John Paul; Wang, Ruiwu; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove Madsen, Leif; Feng, Wei; Chen, Ju (2023-07-07)
      Article
      Accés obert
      Background: A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M+/–, has recently been linked to a new cardiac disorder termed RyR2 Ca2+ release deficiency syndrome (CRDS) as well as left ventricular ...