Exploració per autor "Cascales, L."

Ara es mostren els items 1-3 de 3

    • Design and facile solid-phase synthesis of peptide-based LPS-inhibitors containing PEG-like functionalities 

      Mas Moruno, Carlos; Cascales, L.; Mora, P.; Cruz, L.J.; Perez-Paya, E.; Albericio, F. (Wiley, 2009)
      Article
      Accés restringit per política de l'editorial
      LPS release from Gram-negative bacteria can result in sepsis, a serious systemic inflammatory response to infection that can lead to septic shock and multiple organ failure. Thus, easy-to-synthesize, effective, and safe ...

    • Nanostructure formation enhances the activity of LPS-neutralizing peptides 

      Mas Moruno, Carlos; Cascales, L.; Cruz, L.J.; Mora, P.; Pérez-Payá, E.; Albericio, F. (2008)
      Article
      Accés restringit per política de l'editorial
      Peptides that interact with lipopolysaccharide (LPS) can provide the basis for the development of new antisepsis agents. In this work, several LPS-neutralizing acyl peptides derived from LALF, BPI, and SAP were prepared, ...

    • Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell 

      Cascales, L.; Mas Moruno, Carlos; Tamborero, Silvia; Aceña, J.L.; Sanz, J.F.; Fustero, S.; Cruz, Luis Javier; Albericio, Fernando; Mora, P.; Pérez-Payá, Enrique (2008)
      Article
      Accés restringit per política de l'editorial
      The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially ...