Exploració per tema "Càncer--Aspectes genètics"

Ara es mostren els items 1-6 de 6

    • Deciphering Genomic Heterogeneity and the Internal Composition of Tumour Activities through a Hierarchical Factorisation Model 

      Carbonell Caballero, José; López Quílez, Antonio; Conesa Ortega, David; Dopazo, Joaquín (MDPI, 2021)
      Article
      Accés obert
      Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a ...

    • Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer 

      Heyn, Holger; Vidal, Enrique; Ferreira, Humberto J.; Vizoso, Miguel; Sayols, Sergi; Gomez, Antonio; Moran, Sebastian; Boque-Sastre, Raquel; Guil, Sonia; Martinez-Cardus, Anna; Lin, Charles Y.; Romina, Royo; Sanchez-Mut, Jose V.; Martinez, Ramon; Gut, Marta; Torrents, David; Orozco, Modesto; Gut, Ivo; Young, Richard A.; Esteller, Manel (BioMed Central, 2016-01-26)
      Article
      Accés obert
      Background One of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA methylation profiles is increasingly recognized. ...

    • Hydroxyapatite biobased materials for treatment and diagnosis of cancer 

      Lama Odría, María del Carmen Elizabeth de; Valle Mendoza, Luis Javier del; Puiggalí Bellalta, Jordi (2022-10-01)
      Article
      Accés obert
      Great advances in cancer treatment have been undertaken in the last years as a consequence of the development of new antitumoral drugs able to target cancer cells with decreasing side effects and a better understanding of ...

    • ICO amplicon NGS data analysis: a web tool for variant detection in common high-risk hereditary cancer genes analyzed by amplicon GS junior next-Generation Sequencing 

      López Dóriga, Adriana; Feliubadalo, Lidia; Menendez, Maria Dolores; Lopez Doriga, Sergio; Morón Duran, Francisco D.; del Valle, Jesús; Tornero, Eva; Montes, Eva; Cuesta, Raquel; Campos, Olga; Gómez, Carolina; Pineda, Marta; González, Sara; Moreno, Victor; Capellá Frau, Gabriel José; Lázaro, Conxi (2013-11-01)
      Article
      Accés restringit per política de l'editorial
      Next-generation sequencing (NGS) has revolutionized genomic research and is set to have a major impact on genetic diagnostics thanks to the advent of benchtop sequencers and flexible kits for targeted libraries. Among the ...

    • Identifying cellular cancer mechanisms through pathway-driven data integration 

      Windels, Sam F L; Malod Dognin, Noël; Przulj, Natasa (Oxford University Press, 2022-08-02)
      Article
      Accés obert
      Abstract Motivation Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways ...

    • Signatures of TOP1 transcription-associated mutagenesis in cancer and germline 

      Reijns, Martin A. M.; Parry, David A.; Williams, Thomas C.; Nadeu, Ferran; Hindshaw, Rebecca L.; Royo, Romina (Nature Research, 2022)
      Article
      Accés obert
      The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to ...