Now showing items 1-4 of 4

  • Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles 

    Lanz, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastián (2012-08-14)
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    Microbial poly( β , L -malic acid) was modifi ed with either L -leucine ethyl ester (L) or L -phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took ...
  • Nanoparticles of esterified polymalic acid for controlled anticancer drug release 

    Lanz Landazuri, Alberto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Holler, Eggehard; Ljubimova, Julia; Muñoz Guerra, Sebastián (2014-09-01)
    Article
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    Esterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates capable to form nanoparticles (100–350 nm). Degradation under physiological conditions takes place ...
  • Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs 

    Lanz, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Patil, Rameshwar; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastián (2011-10-10)
    Article
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    PMLA nanoparticles with diameters of 150–250nm are prepared, and their hydrolytic degradation is studied under physiological conditions. Degradation occurs by hydrolysis of the side chain methyl ester followed by cleavage ...
  • Study of molecular structure and vibrational spectra of poly (ß,-1-malic acid) [PMLA] using DFT approach 

    Chaturvedi, D.; Mishra, S.; Tandon, P.; Portilla Arias, Jose Antonio; Muñoz Guerra, Sebastián (Elsevier, 2012-06-07)
    Article
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    Poly (β-L-malic acid) (PMLA) is a biodegradable polymer and it has various important applications in the biomedical field. In the present work the structural and spectral characteristics of PMLA have been studied by methods ...