Now showing items 1-4 of 4

  • Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension 

    Teulon, Jean-Marie; Mahé, Nathalie; Do, Bernard; Nicolaï, Béatrice; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Ghéchot, Christophe (2012)
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    Aging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ...
  • On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form 

    Allouchi, Hassan; Nicolai, Beatrice; Barrio Casado, María del; Céolin, René; Mahé, Nathalie; Tamarit Mur, José Luis; Do, Bernard; Rietveld, Ivo B. (2014-03-01)
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    Solid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. ...
  • Solid-state properties and dehydration behavior of the active pharmaceutical ingredient potassium guaiacol-4-sulfonate 

    Mahé, Nathalie; Nicolai, Beatrice; Barrio Casado, María del; Perrin, Marc Antoine; Do, Bernard; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-05-20)
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    Potassium guaiacolsulfonate is an active pharmaceutical ingredient that has been in use for more than a century, and it is still widely used in cough syrups. Nonetheless, no crystal structure has ever been determined to ...
  • Uniaxial negative thermal expansion in crystals of tienoxolol 

    Nicolaï, Beatrice; Rietveld, Ivo B.; Barrio Casado, María del; Mahé, Nathalie; Tamarit Mur, José Luis; Céolin, René; Guéchot, Christophe; Teulon, Jean-Marie (2012-06-17)
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    The thermal expansion of tienoxolol has been investigated by X-ray powder diffraction up to its melting temperature. The data indicate that the expansion is anisotropic and even negative in one direction of the unit cell. ...