Exploració per autor "Chen, S.R. Wayne"

Ara es mostren els items 1-3 de 3

    • Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity 

      Jiménez Sábado, Verónica; Casabella Ramón, Sergi; Llach, Anna; Gich, Ignasi; Casellas Casanova, Sandra; Ciruela, Francisco; Chen, S.R. Wayne; Guerra Ramos, José Mª; Ginel Iglesias, Antonino; Benítez Iglesias, Raúl; Cinca, Juan; Tarifa Lora, Carmen; Hove-Madsen, Leif (Elsevier, 2023-02-01)
      Article
      Accés obert
      Aims Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because ß-blockers are expected to ...

    • Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice 

      Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
      Article
      Accés restringit per política de l'editorial
      Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ...

    • RyR2 serine-2030 PKA site governs Ca2+release termination and Ca2+alternans 

      Wei, Jinhong; Guo, Wenting; Wang, Ruiwu; Estillore, John Paul; Belke, Darrell; Chen, Yong-Xiang; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S.R. Wayne (2023-01-20)
      Article
      Accés obert
      Background: PKA (protein kinase A)–mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively studied for decades, but the physiological significance of PKA phosphorylation of RyR2 remains ...