• Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa 

    Bosch Presegué, Laia; Ramon Portés, Eva; Toledo, Darwin; Cordomí Montoya, Arnau; Garriga Solé, Pere (2011-05)
    Article
    Accés restringit per política de l'editorial
    The visual photoreceptor rhodopsin undergoes a series of conformational changes upon light activation, eventually leading to the active metarhodopsin II conformation, which is able to bind and activate the G-protein, transducin. ...
  • Hydrophobic amino acids at the cytoplasmic ends of helices 3 and 6 of rhodopsin conjointly modulate transducin activation 

    Bosch Presegué, Laia; Iarriccio Silva, Laura; Aguila Cerda, Mónica; Toledo, Darwin; Ramon Portés, Eva; Cordomí Montoya, Arnau; Garriga Solé, Pere (2011-02-15)
    Article
    Accés restringit per política de l'editorial
    Rhodopsin is the visual photoreceptor responsible for dim light vision. This receptor is located in the rod cell of the retina and is a prototypical member of the G-protein-coupled receptor superfamily. The structural ...
  • Inter-residue interactions in membrane proteins 

    Mayol, Eduardo; Olivella, Mireia; Cordomí Montoya, Arnau; Pardo, Leonardo (Barcelona Supercomputing Center, 2015-05-05)
    Text en actes de congrés
    Accés obert
    Knowing the precise 3D-structure of a protein is crucial to understand its functional mechanism at the molecular level and to develop new pharmacological agents to targeting it. Nowadays only a few hundred integral ...
  • Molecular dynamics simulations of seven-transmembrane receptors 

    Cordomí Montoya, Arnau (Universitat Politècnica de Catalunya, 2008-03-11)
    Tesi
    Accés obert
    Seven transmembrane (7-TM) G protein coupled receptors (GPCR) constitute the largest family of integral membrane proteins in eukaryotes with more than 1000 members and encoding more than 2% of the human genome. These ...
  • Structural characterization of a zinc high-affinity binding site in rhodopsin 

    Darwin, Toledo; Cordomí Montoya, Arnau; Proietti, Maria Grazia; Maurizio, Benfatto; Valle Mendoza, Luis Javier del; Pérez González, Juan Jesús; Garriga Solé, Pere; Sepulcre Sánchez, Francesc (2009-02)
    Article
    Accés restringit per política de l'editorial